As the hallmark bioactive compound in Ashwagandha (Withania somnifera), Withanolides belong to the class of withanolide triterpenoids, with their efficacy substantiated by over 40 global clinical studies. Research demonstrates that this compound significantly reduces cortisol levels by 28%-32% through modulation of the hypothalamic-pituitary-adrenal (HPA) axis (Journal of Ethnopharmacology, 2022), effectively alleviating anxiety and improving sleep quality. Concurrently, it activates macrophage and natural killer (NK) cell activity, elevating immunoglobulin IgG levels by 19% (International Immunopharmacology, 2021) to reinforce immune defense mechanisms. In cognitive enhancement, Withanolides promote synthesis of brain-derived neurotrophic factor (BDNF), enabling a 14% improvement in memory test scores after 8-week continuous supplementation (Frontiers in Neuroscience, 2023). Its antioxidant capacity is particularly remarkable, exhibiting 1.8 times higher free radical scavenging efficiency than vitamin E while significantly reducing oxidative stress marker MDA levels (Phytotherapy Research, 2020). Natural Field employs high-performance liquid chromatography (HPLC) to precisely standardize Withanolides content ≥5%, with its standardized extract demonstrating 3.2-fold enhanced bioavailability compared to conventional preparations, delivering an efficient solution for functional food development.
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