EN
Note: The following content represents the views of DeepSeek only.
Conclusion: Anti-aging requires a comprehensive approach involving diet, exercise, and lifestyle. A single ingredient cannot reverse aging, but scientific combinations can significantly slow the process.
Here are several categories of anti-aging ingredients favored by DeepSeek, along with their scientific basis and application recommendations:
Mechanism: Scavenge free radicals and reduce oxidative damage (one of the core mechanisms of aging).
Resveratrol (grapes, blueberries, red wine): Activates the SIRT1 longevity gene, extending cell lifespan. Clinical trials suggest potential improvements in cardiovascular and metabolic health.
Anthocyanins (blueberries, black goji berries, purple cabbage): Inhibit inflammatory pathways (e.g., NF-κB) and protect skin collagen.
Astaxanthin (Haematococcus pluvialis, salmon): Powerful antioxidant (6000 times stronger than vitamin C), improves skin UV damage.
Vitamins C/E (citrus fruits, nuts): Synergistically protect cell membranes and DNA, but avoid excessive intake (e.g., vitamin E should not exceed 400 IU per day).
Mechanism: Stimulate collagen synthesis or reduce degradation, maintaining skin elasticity.
Collagen peptides (derived from fish scales, bovine bones): Small molecules are more easily absorbed. Clinical studies show improvements in skin moisture and elasticity (e.g., Japanese study: 10g daily for 8 weeks).
Hyaluronic acid (extracted via fermentation): Oral intake may improve skin barrier function, but low molecular weight products are recommended.
Elastin peptides (derived from deep-sea fish): Emerging ingredient, preliminary studies show enhanced skin firmness.
Mechanism: Inhibit chronic inflammation (the “inflammaging” theory) or improve metabolic function.
Omega-3 fatty acids (deep-sea fish oil, flaxseed): Reduce inflammatory factors (e.g., IL-6), prevent cardiovascular aging. Recommended EPA+DHA intake is 250-500mg daily.
Curcumin (turmeric root) + Piperine: Curcumin inhibits the NF-κB pathway but has low bioavailability, requiring combination with black pepper extract (piperine).
Green tea polyphenols (EGCG): Regulate mitochondrial function, potentially delaying cellular aging (requires 3-4 cups of green tea or 300mg extract daily).
Mechanism: Enhance cellular energy metabolism or activate repair mechanisms.
NMN (Nicotinamide Mononucleotide): Increases NAD+ levels, improving mitochondrial function. Effective in animal studies, but limited human data (e.g., a small-scale Japanese trial in 2020 showed improved muscle function).
Coenzyme Q10 (meat, deep-sea fish): Supports mitochondrial energy production, reduces oxidative damage, especially suitable for cardiovascular anti-aging (100-200mg daily).
Alpha-lipoic acid (spinach, broccoli): Both water- and fat-soluble, regenerates other antioxidants (e.g., vitamins C/E).
Mechanism: Influence systemic aging through the gut microbiota-immune axis.
Probiotics/Prebiotics (fermented foods, dietary fiber): Specific strains (e.g., Bifidobacterium lactis B420) may reduce abdominal fat and inflammation.
Short-chain fatty acids (SCFAs) (fermentation products of dietary fiber): Butyrate can inhibit histone deacetylases (HDACs), delaying cellular aging.
Ganoderma polysaccharides: Regulate Th1/Th2 immune balance, animal studies show lifespan extension.
Mechanism: Multi-target regulation, combining traditional experience with modern research.
Ginsenosides (ginseng, Panax notoginseng): Activate the AMPK pathway, improving energy metabolism. Korean studies show fatigue relief.
Goji polysaccharides: Increase SOD activity, Chinese clinical trials show improved antioxidant capacity in the elderly.
Polygonatum polysaccharides: Represent “nourishing yin” in traditional Chinese medicine, animal studies show telomere length extension.
Evidence Strength Variations: Ingredients like NMN and elastin peptides require more human trials, while vitamins C and Omega-3 have substantial evidence.
Synergistic Effects: Composite formulas may be more effective (e.g., vitamin C + collagen peptides for synthesis promotion).
Dosage and Source: Prioritize natural foods (e.g., deep-sea fish over fish oil capsules), and choose high-purity supplements.
Individual Differences: Genetic factors (e.g., APOE4 carriers should be cautious with high-dose antioxidants) and gut absorption capacity affect efficacy.
