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Many natural compounds have a positive impact on brain health. Fisetin powder is one of these intriguing flavonoids, often called "nature's biological response modifiers". These substances are the reason behind the vibrant colors of many fruits, flowers, and plants, playing a crucial role in both plant health and human health.
Fisetin promotes brain health in the following ways:
Activates antioxidant mechanisms to protect brain cells from damage.
Increases glutathione levels in brain cells, further protecting the brain, enhancing detoxification, and boosting cellular energy.
Promotes the growth of new brain cells.
Stimulates brain circuits and signaling pathways related to long-term memory function.
The renowned Salk Institute for Biological Studies in San Diego has conducted extensive research on the effects of fisetin on brain health, studying it as a "cognitive enhancer" and "neurotrophic factor". Cognitive enhancers are known to boost memory and brain function. Other natural compounds with similar effects include lion's mane extract, pyrroloquinoline quinone (PQQ) with coenzyme Q10, resveratrol, and curcumin.
What makes fisetin unique is its function as a neurotrophic factor, supporting the survival, differentiation, and functional maintenance of brain cells. In other words, fisetin not only helps brain cells perform better but also optimizes "brain plasticity." Additionally, fisetin is recognized for its role as natural antioxidants, contributing to cellular protection and overall brain health. This dual action enhances cognitive function while safeguarding neurons from oxidative stress, making fisetin a valuable compound for brain wellness.
Fisetin powder can cross the blood-brain barrier and acts as a cognitive enhancer and neurotrophic agent through a series of complex mechanisms. While fisetin works slightly differently compared to other compounds, it shares many mechanisms with other flavonoids. For example, fisetin has anti-aging properties similar to resveratrol. It is a potent anti-aging agent that helps the body and brain clear senescent cells, allowing healthy cells to thrive or replace them. In this regard, fisetin's efficacy is about twice that of quercetin.
Like other flavonoids, fisetin promotes the production of glutathione, a crucial antioxidant and detoxifier in our cells. Optimizing glutathione levels in the brain has numerous benefits, as it better protects the brain from damage and increases cellular energy levels.
One of the key actions of fisetin is the activation of extracellular signal-regulated kinase (ERK) pathways. ERK stands for "extracellular signal-regulated kinase", where "extracellular" refers to the perimeter of the cell and "kinase" refers to a class of enzymes. Essentially, ERK gets activated when external signals trigger a response within the cell.
Fisetin powder helps brain cells generate proteins crucial for the structure and function of brain cells, especially at synapses (the communication nodes between cells). It also reduces various inflammatory responses within these synaptic connections.
